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Migraine Increases Risk Of Depression In Women
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Author : Rupert Shepherd (Medical News Today )
Date : February 23, 2012
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Research released today and scheduled to be presented at the American Academy of Neurology's 64th Annual Meeting in New Orleans, April 21 to April 28, shows that women who have a tendency for migraines or have had them in the past, have a greater risk for developing depression.

The study gathered data on more than 36,000 women, who were all classified as not having depression. They were enrolled in the Women's Health Study and gave information about their history of migraines.

The women were categorized as either having :

  • Active migraine with aura
  • Active migraine without aura
  • Past history of migraine (but not within the last year)
  • No history of migraine
The women also gave information about diagnoses of depression.

From 36,154, a total of 6,456 had current or past problems with migraines, and during the following 14 years of the study, more than half of them developed depression.

Those that had a history of migraines were nearly twice as likely to develop depression as those that had no history of the affliction. The results did not vary substantially, regardless of the type of migraine. Those with aura, which is described as visual disturbances that appear as flashing lights, zigzag lines or a temporary loss of vision, had the same risks as other types of migraine.

Tobias Kurth, MD, ScD, with Brigham and Women's Hospital in Boston and Inserm in France and a Fellow of the American Academy of Neurology said :

"This is one of the first large studies to examine the association between migraine and the development of depression over time ... We hope our findings will encourage doctors to speak to their migraine patients about the risk of depression and potential ways to prevent depression."


It's useful information that patients and doctors alike should be aware of when treating depression.
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Link Between Migraine and Blood Vessels in Brain
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Author : Sheela Philomena
Date : January 20, 2011
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In a recent work MRI was used to study the brains of migraine sufferers and has shown that a higher proportion of these patients exhibit lesions of the brain micro-vessels. Researchers further evaluated the impact of migraine on cognitive function. The research affirms the existence of a link between migraine and blood vessels in the brain.

Lesions of the brain micro-vessels, visible on cerebral MRI images, can be of various kinds: white-matter hyperintensities and, more rarely, silent infarcts leading to loss of white-matter tissue.

They result from a deterioration of the small cerebral arteries that supply blood to the brain's white matter, the material which ensures, among other things, the passage of information between different parts of the brain.

These lesions are observed in almost all elderly people. However, their severity varies greatly from one individual to the next. Moreover, it has been shown that they are more severe among hypertension sufferers and diabetics.

A large quantity of hyperintensities leads to many cerebral complications: cognitive deterioration, increased risk of Alzheimer's disease, depression, movement disorders and increased risk of stroke.

Moreover, according to several studies, the presence of a large quantity of this type of brain lesion increases the risk of cognitive deterioration (reasoning, memory, etc.) and of Alzheimer's disease. This is why the research team coordinated by Christophe Tzourio, director of the Inserm-University Pierre et Marie Curie Mixed Research Unit 708 "Neuroepidemiology", advanced the hypothesis that migraines could "damage" the brain.

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Women Who Suffer Migraine With Aura Have Better Outcomes After Stroke
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Author : Karen Astle, American Heart Association
Date : December 01, 2010
True experience on Migraine herbal medicine and alternative Migraine treatment articles


Women with a history of migraine headache with aura (transient neurological symptoms, mostly visual impairments) are at increased risk of stroke. However, according to new research reported in Circulation: Journal of the American Heart Association stroke events in women with migraine with aura are more likely to have mild or no disability compared to those without migraine.

In a new analysis of the Women's Health Study involving 27,852 women over 13.5 years, researchers found those who have migraine with aura and who experience an ischemic stroke were twice as likely to have no significant disability from stroke.

"The message from this study should be reassuring for migraineurs," said Tobias Kurth, M.D., Sc.D., the study's principal author and associate epidemiologist at Brigham and Women's Hospital in Boston, Mass.

"It is important for women who have migraine with aura to know that their risk of stroke is considerably low and there is high likelihood of a migraine-associated stroke being mild."

The reason for these results is unclear. But Kurth, who is also director of research at INSERM in Paris, France, speculated that mechanisms, perhaps involving smaller vessels - not the traditional mechanisms for stroke, lead to a smaller size stroke.

Compared to those without migraine history, women with migraine and aura were more likely to have a good to excellent functional outcome - defined as having no symptoms and no significant disability, researchers said.

Women participating in the study were divided into four groups: 22,723 who reported no migraine history; 5,129 who reported a migraine history; 3,612 who had active migraine; and of those who reported active migraine, 1,435 reported active migraine with aura.

Researchers evaluated functional ability after stroke at hospital discharge using the modified Rankin Scale, a seven-point scale that measures degree of impairment.

At the onset of the study, women completed a questionnaire about their headaches that allowed classification into the groups of migraine with and without aura, history of migraine or no history of migraine. Each following year, the women reported new medical conditions, including transient ischemic attack (TIA) or stroke, which were confirmed after medical record review.

During 13.5 years of follow-up, 398 TIAs and 345 ischemic strokes occurred.

Women in the study were primarily Caucasian, average age 55, healthy and working in the healthcare field.

There is currently little reason to believe that the association differs for women with other characteristics or men, Kurth said.

The first author is Pamela M. Rist, M.Sc., a doctoral student at the Harvard School of Public Health and research fellow at Brigham and Women's Hospital. Other co-authors are: Julie E. Buring, Sc.D.; Carlos S. Kase, M.D.; Markus Schurks, M.D., M.Sc. Author disclosures are on the manuscript.

The Women's Health Study is supported by grants from the National Heart, Lung, and Blood Institute and the National Cancer Institute. Grants from the Donald W. Reynolds, Leducq and Doris Duke Charitable foundations funded part of the study.

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Gene Linked To A Common Form Of Migraine
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Author : Sophie Langlois, University of Montreal
Date : September 28, 2010
True experience on Migraine herbal medicine and alternative Migraine treatment articles


An international study led by scientists at Universite de Montreal and University of Oxford, has identified a gene associated with common migraines. Their findings show that a mutation in the KCNK18 gene inhibits the function of a protein called TRESK. TRESK normally plays a key role in nerve cell communication. Published in Nature Medicine, this study may have implications for people who suffer from recurrent headaches, which include more than six million Canadians.

Previously, genes for migraine have been found only in a rare form involving headaches combined with limb weakness limited to one side of the body. "We focused on the more common types of migraine, without this muscle weakness, in our study, and looked at genes controlling brain excitability," says lead author Ron Lafreniere, Associate Director of the Centre of Excellence in Neuromics of the Université de Montréal (CENUM).

The researchers compared the DNA from migraine sufferers to that of non-sufferers. "We found a mutation in the KCNK18 gene that interrupts TRESK function in one large family suffering from migraine with aura," say Lafreniere. "When we tested everyone in the family, all those who suffered from migraine also had the mutation."

Aura migraines are those that are preceded or accompanied by sensory warning symptoms or signs (auras), such as flashes of light, blind spots or tingling in an arm or leg. The ensuing headache can be associated with sensitivity to lights, sounds, and smells, as well as nausea and occasional vomiting.

Mutation results in incomplete TRESK protein

The mutation causes production of an incomplete form of TRESK which disrupt the normal functioning of this protein. The end result is an alteration in the electrical activity (excitability) of cells. "We now have direct evidence that migraine is a nerve excitability problem and have highlighted a key causal pathway in migraine' says the joint lead author, Dr Zameel Cader from the MRC Functional Genomics Unit at Oxford.

TRESK present in migraine-relevant areas

Cell culture and in vitro experiments revealed that TRESK is present in certain neurons of the brain. "We showed that TRESK is in specific neuronal structures (trigeminal ganglia and dorsal root ganglia) that have been linked to migraine and pain pathways," says Lafreniere.

"This is a highly significant finding because activation of trigeminal ganglion neurons is central to migraine development and increased activation of these neurons could very plausibly increase the risk for developing a migraine attack," explains senior author Guy Rouleau, a Université de Montréal professor and Director of the Sainte-Justine University Hospital Research Center. "While TRESK mutations are present only in a small number of migraine sufferers, because we believe that TRESK helps control the excitability of nerve cells, our results suggest that increasing TRESK activity pharmacologically may help reduce the frequency or severity of migraine episodes, irrespective of their origin."

About migraines

Migraines are debilitating chronic headaches that can cause pain for hours or days. They can begin in the early teen years and may be triggered by many things, including stress, odors, certain foods, alcohol, etc.

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Food and environmental allergies are frequently linked to migraines, as is liver dysfunction. Constipation, stress, menopause, and a lack of exercise should also be considered as possible causes.
 
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Migraine is a throbbing and normally intense headache in one half of the head usually. It can affect people of all ages. The blood vessels in the brain dilatation and draw together with stimulation of nerves near the blood vessels. More...
 
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Migraine sufferers should avoid such as alcohol, foods that are known to cause attacks such as caffeine and make sure have enough sleep. More...
 
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Migraine juga di kenali sebagai vascular headache, manakala dalam bahasa Greek ia di kenali sebagai henimikrania yang bermaksud sebelah tengkorak. More...
 
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A migraine can be disabling - with symptoms so severe, all you can think about is finding a dark, quiet place to lie down. Up to 17 percent of women and 6 percent of men have experienced a migraine.
 
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A migraine headache is a severe pain felt on one, and sometimes, both sides of the head. The pain is mostly in the front around the temples or behind one eye or ear.
 
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